Cinque Terre, Italy
There is no airport at the Cinque Terre, but there are international airports in nearby Pisa, Genoa, Milan, Florence, Bologna, and Turin.
Cars are not allowed in the Cinque Terre. If you must drive, there is parking outside the towns, but it is limited and expensive. Train is your best bet. They run regularly between the towns and nearby La Spezia is a hub with trains getting to Florence in just over 2 hours.
The ferry runs (weather permitting) to all the towns in the Cinque Terre (except Corniglia) and Portovenre. Reservations are not needed for parties less than 20 people.
There is also a separate ferry service that runs from the Cinque Terre to Portofino. No advance reservations.